I tried dissolving sucralfate and syringing it down. It was a big mess and basically pointless. I know you're supposed to give it on an empty stomach, but I don't imagine what I'm going to suggest would be enough to mess things up. Try wrapping it in just enough greasy ground beef to cover it. Then shove it down. I have to give Chase at least 16 pills a day and he is rarely cooperative. So I just started wrapping them in ground beef because they slide down much easier. I also developed a little trick because he frequently tries to chomp on me while I'm trying to get the pills down. I stand on one side of him an slide his lip, for lack of a better term, down so it covers one side of his teeth. Usually it's the skin on the right side of his face that I slide down and over the right side of his mouth/teeth. When I do this he won't bite down as hard because he'll also be biting himself. I still wrestle with him three times a day, but it's a lot easier than it used to be.