Years ago when I had my first greyhound, rascal, he was unable to empty his bladder completely due to nerve issues after a battle with FCE. Our vet put him on Orbax...no mention of problems giving it with meals. He was on it for an extended period of time as it was a constant battle for him to not develop an infection. It kept him infection free but he wasn't battling an on going issue. I thought it was a pretty heavy duty antibiotic.