We had a beautiful lab/NS duck tolling retriever cross who was thus diagnosed. She started falling over, having small bleeds I guess. After investigation, she was found to have tumours on her spleen and in her heart. She lost her appetite, and became increasingly distressed over the next couple of months until it was clear there was almost no joy in her life. However, even on her what turned out to be her last day, she still found the energy to follow the sunspots around the house, clambering on to chairs and beds. We didn't want to take any pleasure she was still finding in her existence until we were sure she was sure. Sorry, not a pretty story...