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THE PET HEALTH LIBRARYBy Wendy C. Brooks, DVM, DipABVP
Educational Director, VeterinaryPartner.com
Immune Mediated Hemolytic Anemia (IMHA)
(Formerly known as autoimmune hemolytic anemia or AIHA)
Immune-mediated hemolytic anemia is a condition where the patient’s immune system begins attacking her own red blood cells. What occurs on a microscopic level is that the branch of the immune system that produces antibodies begins to direct them against the patient’s own red blood cells. The red blood cells quickly become coated with tiny antibody proteins, essentially marking these red blood cells for destruction. When too many red blood cells are destroyed the patient is said to be anemic and will feel cold and weak. Because the red blood cells are being destroyed internally (and not lost through bleeding), the patient will become yellow-tinged (jaundiced) rather than pale (see picture below).
http://www.veterinarypartner.com/Content.plx?A=1390
it can be caused by Rimadyl and I know because rimadyl killed my first greyhound. And yes, it could happen from one dose