When they get to that age, I treat them with antibiotics like Clavamox, just because if there is a problem.
Chiropractic helps a lot. I wonder if that is why, so far (knock on wood) none of mine have had urinary incontinece. Sleep turds yes--urine no Acupuncture would help too.
DES can affect platelets and you have to check every so often.
PPA - the side effects can be stroke.