My story is a little bit different because I did not get a sign from Bailey. She had stomach cancer and we had to make a decision right away because she couldn't keep any food down.
She was bright, alert, followed me around, went for walks, but couldn't keep her food down. I knew she was getting tired though and she couldn't be cured...so I made the decision that if she couldn't eat she would continue to lose weight and be malnourished, and that would not be fair to her, and would be selfish of me.
I always felt I let her go too early, but I didn't want her to suffer any more and she would only be alive because of my selfishness and I knew it would be painful.
After reading these stories, perhaps it was the right decision, even if Bailey never gave me any signs. A friend (gazehund) said she'd rather let a hound go one day too early rather than one day too late, and I kept this in mind when I was going through this.
I just wanted to point out that I didn't get a sign, but I had to listen to my heart and do what was best for Bailey because I loved her so much.