We've heard some horror stories about using Advantix on greyhounds. I know at least one vet that will not recommend Advantix for dogs when the family also has cats.
Flea and Tick treatment is a personal decision, based on what is best for your dog, your household and your area of the country. All medical treatment and advice should always come from your Vet and not the internet.
Agreed! I should have added that. Flea/tick prevention is not as simple as the OP makes it sound.
Ditto that. Starting with the Lyme vaccine. No thanks, not for my dogs. I did it once and Future had such a nasty reaction to it I have never done it again. That was 10 years ago.