Yes, I use Advantage Multi. My vet recommends it as the absolute best product for heartworm + parasites; it replaced Sentinel as what he prescribes. I HATE having to use two topicals a months most of the year (also Frontline since Advantage Multi doesn't do ticks), but if that's what my vet honestly thinks is superior (he tries to be very cutting-edge with the best treatments), we'll go with it. Anyway, no problem here.
It's also safe to use with cats in the house, BTW.