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Dundee's Result From Exploratory Surgery


Guest DundeeToddsMom
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Guest DundeeToddsMom

Sorry this is sol long, but here is portion of the histology report. Please let me know if anyone has heard of this before. I don't understand what this is..how could I have missed this? I had him in the vets 3-4 times before being referred to a specialists. I don't even know what kind of cancer, other than fast moving - rare - non-common to greys from the Dr.

 

Clinical History: 4-6 week history of appetence & weight loss. Blood work reveals moderate anemia, severe hypoproteinemia & mild liver enzyme elecation. Liver is very mottled & irregular; spleen is very nodular on gross appearance.

 

Liver: dark brown, edges are rounded. Multiple off-white and less irregular area noted. Cut surface is dark brown to bile stained.

 

Spleen: dark brown. No distinct lesions or masses are noted.

 

Stomach: off-white-pale yellow. No distinct leisons.

 

Microscopie:

Liver - specimen consists of sections of liver in which there are disseminated foci of histiocyte/fibrohistiocyte infiltrate of the sinusoids, expanding the sinusoids & disrupting hepatic cords; similar, cohesive aggregates of cells are found in hepatic and portal veins; extramedullay hematpoiesis and numerous pigment laden histiocytes accompanying the inifltrate; regionally extensive hemorrage; hepatocelluar individualiztion & necrosis; canalicular cholestasis , regional lymphatic & venous dilation.

 

Spleen: Regional hemorrhagiv infarct, multiple histiocytic nodules composed of cells with abundant cytoplasm & vesicular oval to irregular, vesicular nuclei with variably prominent nucleoli; multifocal extramedullary hematpoiesis; siderotic plaques.

 

Stomach: Mild lymphoplasmacytic mucosal infiltrate.

 

Small intestine: occasional dilated & irregular glands and mild lymphoplasmacytic infiltrate in the lamia propria

 

Lymph node: with diffuse sinus histicytosis with RBC's in sinuses

 

Diagnois: Liver & spleen leisons are most unusual. The extensiveness of the histiocytic infiltrate in the liver sinusoids together with the finding of histiocytic aggregates in vessels warrants consideration of this lesion as a manifestation of a histiocytic sarcoma or neoplastic histiocytosis. The most current terminology for some of these lesions is macrophagic sarcoma, according to researchers at University of CA. Prognosis is guarded. Other sites of involvement, especially nodes or bone marrow are possible.

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Guest debi5475
Sorry this is sol long, but here is portion of the histology report.  Please let me know if anyone has heard of this before.    I don't understand what this is..how could I have missed this?  I had him in the vets 3-4 times before being referred to a specialists. I don't even know what kind of cancer, other than fast moving - rare - non-common to greys from the Dr. 

 

Clinical History:  4-6 week history of appetence & weight loss.  Blood work reveals moderate anemia, severe hypoproteinemia & mild liver enzyme elecation.  Liver is very mottled & irregular; spleen is very nodular on gross appearance.

 

Liver:  dark brown, edges are rounded.  Multiple off-white and less irregular area noted.  Cut surface is dark brown to bile stained.

 

Spleen:  dark brown.  No distinct lesions or masses are noted.

 

Stomach:  off-white-pale yellow.  No distinct leisons.

 

Microscopie: 

Liver - specimen consists of sections of liver in which there are disseminated foci of histiocyte/fibrohistiocyte infiltrate of the sinusoids, expanding the sinusoids & disrupting hepatic cords; similar, cohesive aggregates of cells are found in hepatic and portal veins;  extramedullay hematpoiesis and numerous pigment laden histiocytes accompanying the inifltrate; regionally extensive hemorrage; hepatocelluar individualiztion & necrosis; canalicular cholestasis , regional lymphatic & venous dilation.

 

Spleen:  Regional hemorrhagiv infarct, multiple histiocytic nodules composed of cells with abundant cytoplasm & vesicular oval to irregular, vesicular nuclei with variably prominent nucleoli; multifocal extramedullary hematpoiesis; siderotic plaques.

 

Stomach: Mild lymphoplasmacytic mucosal infiltrate.

 

Small intestine:  occasional dilated & irregular glands and mild lymphoplasmacytic infiltrate in the lamia propria

 

Lymph node:  with diffuse sinus histicytosis with RBC's in sinuses

 

Diagnois:  Liver & spleen leisons are most unusual.  The extensiveness of the histiocytic infiltrate in the liver sinusoids together with the finding of histiocytic aggregates in vessels warrants consideration of this lesion as a manifestation of a histiocytic sarcoma or neoplastic histiocytosis.  The most current terminology for some of these lesions is macrophagic sarcoma, according to researchers at University of CA.  Prognosis is guarded.  Other sites of involvement, especially nodes or bone marrow are possible.

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Guest auntiesara

I hope one of the vets or vet techs can answer you. We looked to see if we could find anything in our books and found nothing - did not do an internet search, it's probably the best thing to try. All I can find is that histocytes are a sort of scavenger white cell which cleans up cellular debris and microorganisms and are part of the system that produces an immune response. It sounds very serious, similar to a blood or lymphatic cancer, but I really don't know. Do they have a treatment for poor Dundee? Chemo? Did they tell you anything else? We are so sorry to hear this!

Charlie

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Guest LynnM

I'm coming up with nada.... anytime a referral or specialist says "Most unusual" or "Sh*t, I dunno" (yes, I've been told that), I tend to get more than a tad worried.

 

Your best bet is to look at the human side of things, perhaps a search at www.pubmed.com (Medline) or head to your nearest medical school and their library.

 

Lynn

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No help or advice but sending good wishes for Dundee :candle

Deerhounds Darcy, Duffy, Grace & Wellington, Mutts Sprout & Buddy, Lurchers Ned & Jake plus Ella the Westie + cats. Remembering Del, Jessie, Maddison, Flo, Sally, Stanley, Wallace, Radar, Mokka, Oki cat, Tetley, Poppy & Striker.

 

Please visit our web store at http://www.dogsndubs.com for our own range of Greyhound related clothing for humans!

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Guest DundeeToddsMom

Oops - I should have mentioned again that we had to help Dundee cross the bridge 1 month ago yesterday 5-16-05 at 6:30pm.

 

I can't bring myself to change my signature line yet or my screen name. It took me this long to be able to ask you guys this question about his results. I just need to understand and I was such a mess when the Dr was originally telling me.

 

I'm sorry for the misunderstanding.

 

PS There is a long thread in Health & Medical when I was going through this terrible ordeal. Thank you everyone for you kind word and prayers

Edited by Dundee_Todds Mom
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Oops - I should have mentioned again that we had to help Dundee cross the bridge 1 month ago yesterday 5-16-05 at 6:30pm. 

 

I can't bring myself to change my signature line yet or my screen name.  It took me this long to be able to ask you guys this question about his results.  I just need to understand and I was such a mess when the Dr was originally telling me.

 

I'm sorry for the misunderstanding.

 

PS There is a long thread in Health & Medical when I was going through this terrible ordeal.  Thank you everyone for you kind word and prayers

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i'm sorry, i remembered that, but when i went to look for the threads to confirm that Dundee was no longer with you, I couldn't find anything :blush

 

I found this article; I don't know if it was relevent or not (I didn't post the link because I couldn't find those threads)

 

Update on Feline Fibrosarcoma

siggy_robinw_tbqslg.jpg
Xavi the galgo and Allen the cat. Missing Iker the galgo ?-Feb.9/19, Treasure (USS Treasure) April 12/01-May 6/13, Phoenix (Hallo Top Son) Dec.14/99-June 4/11 and Loca (Reko Swahili) Oct.9/95 - June 1/09.

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Guest auntiesara

So sorry this happened to you and poor Dundee. I remembered that he had been quite sick, but somehow I missed or forgot that you had lost him. I always loved his name. I'm so sorry he's gone.

Charlie

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Sorry to read about your loss. If the diagnosis of histiocytic sarcoma was correct then that was a bad disease that is ultimately fatal. : ( The biopsy was unusual in that the person who read it even mentioned it and stated "warrants consideration" and not "is diagnostic for". In cases like these I would typically have lab send the sample somewhere else for a 2nd opinion. If it were in Ohio, I'd probably send it to OSU and have them read it and then consult with Dr. Couto their oncologist on how to proceed as this is a rare diagnosis. I don't have very much info. to share on this condition as it is rare... but this is what I could track down:

 

Malignant histiocytosis is often characterized by the systemic proliferation of large, pleomorphic, single and multinucleated histiocytes with marked cellular atypia and phagocytosis of erythrocytes and leukocytes. These histiocytes are pleomorphic, large, discrete, markedly atypical mononuclear cells; nuclei are round to oval or reniform. Features of malignancy that are usually present include marked anisocytosis and anisokaryosis, prominent nucleoli, bizarre mitotic figures, marked phagocytosis of erythrocytes, leukocytes, and other tumor cells, and moderate amounts of lightly basophilic, vacuolated cytoplasm. The presence of multinucleated giant cells also supports the diagnosis. Malignant histiocytosis is a rapidly progressive, ultimately fatal, disorder that has been described in adult dogs, including Bernese mountain dogs and other breeds; an increased incidence of the disorder has been suggested in the golden retriever and flat coated retriever breeds.

Bill

Lady

Bella and Sky at the bridge

"Until one has loved an animal, a part of one's soul remains unawakened." -Anabele France

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Guest DundeeToddsMom

Thank you Dr Feeman for taking the time to respond.

 

They did have a second opinion on the samples and they agreed.

I wish they could have diagnoised this much faster so my Sweet Dee wouldn't have had to suffer.

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  • 3 years later...
Again I'm sorry for your loss...could you send it to Dr Feedman and get his opinion? Maybe he could offer some answers.

 

My 10 year old girl was just diagnosed w/ histiocytic sarcoma. From what I've been able to research, not good. Any ideas since Dundees diagnosis? Rapidly advancing nodules in her spleen and liver.[topic=cancer

histiocytic sarcoma]histiocytic sarcoma

cancer[/topic]

 

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Guest vahoundlover
Again I'm sorry for your loss...could you send it to Dr Feedman and get his opinion? Maybe he could offer some answers.

 

My 10 year old girl was just diagnosed w/ histiocytic sarcoma. From what I've been able to research, not good. Any ideas since Dundees diagnosis? Rapidly advancing nodules in her spleen and liver.[topic=cancer

histiocytic sarcoma]histiocytic sarcoma

cancer[/topic]

 

 

I am so sorry. :( My prayers are with you and your baby girl.

 

You might want to start a new thread asking for help, people may see the old date at the top and not scroll down.

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Again I'm sorry for your loss...could you send it to Dr Feedman and get his opinion? Maybe he could offer some answers.

 

My 10 year old girl was just diagnosed w/ histiocytic sarcoma. From what I've been able to research, not good. Any ideas since Dundees diagnosis? Rapidly advancing nodules in her spleen and liver.[topic=cancer

histiocytic sarcoma]histiocytic sarcoma

cancer[/topic]

 

You'll want to consult with Dr. Couto at Ohio State University. However, I don't think there is much that can be done, as I recall. Tyler was diagnosed with malignant histiocytosis at OSU in November 2006. He actually had it as a bone tumor in his leg, but scans of the rest of his body before amputation showed that his spleen was starting to show involvement, so we cancelled the amputation, took him home, spoiled him and let him go. As I recall, radiation and/or chemotherapy aren't really effective against histiocytic sarcoma, which is why we cancelled the amputation - he would've been sick again by the time he healed from the surgery.

 

I'm sorry. It sucks. But Dr. Couto is the one to talk to about this.

Deanna with galgo Willow, greyhound Finn, and DH Brian
Remembering Marcus (11/16/93 - 11/16/05), Tyler (2/3/01 - 11/6/06), Frazzle (7/2/94 - 7/23/07), Carrie (5/8/96 - 2/24/09), Blitz (3/28/97 - 6/10/11), Symbra (12/30/02 - 7/16/13), Scarlett (10/10/02 - 08/31/13), Wren (5/25/01 - 5/19/14),  Rooster (3/7/07 - 8/28/18), Q (2008 - 8/31/19), and Momma Mia (2002 - 12/9/19).

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I am sorry I have no help, but I wanted to send prayers and white light with some hugs. :bighug:hope:hope:hope:candle

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Darlene Mom to: Aladdin, Sophie ,Pongo, Jasmine, Relic Forever in our Hearts Champ at the Rainbow Bridge.

Let a greyhound race into your heart Adopt

Bay Area Greyhound Adoptions INC. Naples/ Fort Myers Chapter

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This topic is from June 2005.

Greyhound angels at the bridge- Casey, Charlie, Maggie, Molly, Renie, Lucy & Teddy. Beagle angels Peanut and Charlie. And to all the 4 legged Bridge souls who have touched my heart, thank you. When a greyhound looks into you eyes it seems they touch your very soul.

"A dog is the only thing on earth that loves you more then he loves himself". Josh Billings

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Dr. Couto's e-mail is couto.1@osu.edu

Deanna with galgo Willow, greyhound Finn, and DH Brian
Remembering Marcus (11/16/93 - 11/16/05), Tyler (2/3/01 - 11/6/06), Frazzle (7/2/94 - 7/23/07), Carrie (5/8/96 - 2/24/09), Blitz (3/28/97 - 6/10/11), Symbra (12/30/02 - 7/16/13), Scarlett (10/10/02 - 08/31/13), Wren (5/25/01 - 5/19/14),  Rooster (3/7/07 - 8/28/18), Q (2008 - 8/31/19), and Momma Mia (2002 - 12/9/19).

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