Guest OPointyDog Posted June 15, 2016 Share Posted June 15, 2016 (edited) Our 6-year-old female greyhound Zoe was diagnosed with Protein Losing Enteropathy in April. Backstory: Zoe had been having diarrhea on and off, but nothing serious, and then I came home from work one day and she looked like she had swallowed a watermelon she was so swollen. Got her to the vet, and the fluid was ascites. They did bloodwork, and found her total protein levels were low, as was the albumin, and the vet suspected PLE. They did an x-ray of her heart, and drew more blood (B12 level and some more detailed liver values). B12 was low, so we started supplementing. Heart appeared normal. Liver values were normal. Started her on Tylan powder and a bland, low fat diet, and got an appointment to go to a specialist. Within 5 days, she had cleared the ascites and the diarrhea was improved, but she was still lethargic, and had lost about 7 lbs from her normal weight (70lbs to 63). We took her to an internal medicine specialist, and they did an ultrasound, and then scheduled an endoscopy. Ultrasound did not show any masses, but did reveal several blood clots, including a large one in her portal vein that seemed to be clearing. That's likely what caused the ascites. Endoscopy revealed that the root cause of the PLE is inflammatory bowel disease; moderate thickening and inflammation in the upper intestines, but no masses or lesions and biopsies revealed no cancer. (Whew!) So about 5 weeks ago, she started on prednisone and a hypoallergenic diet. Here's what she's currently getting: Prednisone, 20 mg (once/daily) Tylan Powder, 1/4 tsp (twice/daily) 20mg aspirin, 1 daily (to prevent clotting) B12 shots (every other week) Royal Canin Hypoallergenic dry food (4 cups/day) + canned of the same Hills Hypoallergenic treats Dried banana chips We had her bloodwork repeated last week, and everything was normal except total protein (now 4.1) and albumin (now 2.2). I've read online that greyhound values for total protein run lower, but hers is still below the normal range. Zoe has regained her energy level (and then some!) and is eating and pooping normally. She's drinking more than normal and having some accidents, but I think that's the prednisone. She has gained 2.5 lbs, and seems to be gaining about 0.5 lbs per week (currently 65.5). It was hell at first, but she does seem to be tolerating the prednisone reasonably well at this point. The internal medicine specialist seemed to think that if Zoe were going to return to normal values on the current medicines, she would have done it by now and suggested adding either chlorambusil or cyclosporine to her treatment (both are immunosuppressants). My feeling was that we didn't know if her values had plateaued yet, and I'd like to keep things the same and test again in a month. For now we're waiting - am I being too conservative? Anybody had greyhounds with PLE on chlorambusil or cyclosporine? The vet specialist seemed to prefer the first, as it was easier to dose and was generally better tolerated. Any thoughts or suggestions on long-term management of PLE are appreciated! Edited June 15, 2016 by OPointyDog Quote Link to comment Share on other sites More sharing options...
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