Guest peacehound Posted December 29, 2013 Share Posted December 29, 2013 Peace will soon be 12 and has been on Proin for 5 years without any problems. Each time we tried to stop the drug she would begin to leak. This week, she has had two accidents which occurred within 2 hours of her walks and was a fairly large amount. At first we blamed it on traveling for the holidays and a change of routine but the last accident occurred today at home. Of course, she will be going to the vet on Monday as soon as I can get an appointment but I just wondered if anyone on here has experienced this issue. I have to go back to work after New Years and I don't want her to have accident and get sore when no one is here to clean her. My husband and I work different times but she still has to go 6 hours without going outside. Has anyone switched to DES after using Proin? Any info is appreciated. Right now, her Proin dose is 62mg every 12 hours, she weighs 67 pounds. Perhaps her dosage needs adjusted? thanks so much! Quote Link to comment Share on other sites More sharing options...
KF_in_Georgia Posted December 29, 2013 Share Posted December 29, 2013 It could be an honest-to-goodness UTI--especially if she's actually peeing rather than leaking. If so, that'll be antibiotics. Quote Kathy and Q (CRT Qadeer from Fuzzy's Cannon and CRT Bonnie) and Jane (WW's Aunt Jane from Trent Lee and Aunt M); photos to come. Missing Silver (5.19.2005-10.27.2016), Tigger (4.5.2007-3.18.2016), darling Sam (5.10.2000-8.8.2013), Jacey-Kasey (5.19.2003-8.22.2011), and Oreo (1997-3.30.2006) Link to comment Share on other sites More sharing options...
gracegirl Posted December 29, 2013 Share Posted December 29, 2013 Pro in always worked well for Grace. She was on it for about 5 years until I had to say goodbye one night at the e-vet. She was on one pill in the AM and 1/2 pill in the PM. I'm sorry that I can't remember the dosage by mg, maybe 75mg?? Anyhow, at one point I tried giving her 1/2 pill with each meal (AM and PM) and she started leaking after a few days. Back to a full pill in the morning = no leaking. If she does not have a UTI I would consult with your vet about a safe dose increase. Keep us posted! Quote Poppy the lurcher 11/24/23 Gabby the Airedale 7/1/18 Forever missing Grace (RT's Grace), Fenway (not registered, def a greyhound), Jackson (airedale terrier, honorary greyhound), and Tessie (PK's Cat Island) Link to comment Share on other sites More sharing options...
dmswartzfager Posted December 29, 2013 Share Posted December 29, 2013 Another possibility besides Proin and DES is Incurin, which came onto the market about a year ago: http://www.merck-animal-health-usa.com/news/2012-10-1.aspx Quote Deanna with galgo Willow, greyhound Finn, and DH BrianRemembering Marcus (11/16/93 - 11/16/05), Tyler (2/3/01 - 11/6/06), Frazzle (7/2/94 - 7/23/07), Carrie (5/8/96 - 2/24/09), Blitz (3/28/97 - 6/10/11), Symbra (12/30/02 - 7/16/13), Scarlett (10/10/02 - 08/31/13), Wren (5/25/01 - 5/19/14), Rooster (3/7/07 - 8/28/18), Q (2008 - 8/31/19), and Momma Mia (2002 - 12/9/19). Link to comment Share on other sites More sharing options...
Guest greybookends Posted December 29, 2013 Share Posted December 29, 2013 Sheana is on it and we had to increase her dosage a couple of years ago. I'd check for a UTI first but she could need an increase in the dosage. When she first stated it was a quarter pill twice daily, now it is half a pill twice daily. She is twelve and has been on it for about 7-8 years now. Quote Link to comment Share on other sites More sharing options...
tbhounds Posted December 29, 2013 Share Posted December 29, 2013 Exam needed. She could be drinking more due to another health condition. I would have her examined and have some bloodwork and an urinalysis run. Try to bring in a first morning urine sample. Quote Link to comment Share on other sites More sharing options...
Guest peacehound Posted December 29, 2013 Share Posted December 29, 2013 she will go to the vet tomorrow or Tuesday, whenever they can get her in, I plan to just have her complete senior bloodwork panel done, she is due next month anyways. Any suggestions on how to catch that morning pee? Quote Link to comment Share on other sites More sharing options...
cleptogrey Posted December 30, 2013 Share Posted December 30, 2013 simple, follow her out, as soon as she starts to pee place a flat plastic container under her- ie- cool whip container or something even flatter. she won't know and you will catch enough. at the obgyn they always tell you to catch your urine mid stream, why not for dogs? Quote Link to comment Share on other sites More sharing options...
tbhounds Posted December 30, 2013 Share Posted December 30, 2013 Just make sure the container you use is super clean. We had a client bring urine in an old jelly jar--surprise the urine showed a high glucose ;-). It's important to get the first a.m. sample to check her urine concentration. Quote Link to comment Share on other sites More sharing options...
Guest peacehound Posted December 31, 2013 Share Posted December 31, 2013 Peace will be starting DES as soon as the compounding pharmacy sends it to me. The vet said to give her both the DES and the Proin and then to wean down the amount of Proin given. It scares me to give my old girl any additional medication. Anyone have luck with DES? Part of me says to just live with the urine and replace floors later but I am afraid it will burn her if she lays in it while we are at work. sigh Quote Link to comment Share on other sites More sharing options...
tbhounds Posted December 31, 2013 Share Posted December 31, 2013 Peace will be starting DES as soon as the compounding pharmacy sends it to me. The vet said to give her both the DES and the Proin and then to wean down the amount of Proin given. It scares me to give my old girl any additional medication. Anyone have luck with DES? Part of me says to just live with the urine and replace floors later but I am afraid it will burn her if she lays in it while we are at work. sigh Sounds like a game plan. To be honest I would never use proin with one of my hounds. The "bad" side effects seen with DES is not really an issue with the low dosage we use to control incontentence. Quote Link to comment Share on other sites More sharing options...
greyhoundlov Posted December 31, 2013 Share Posted December 31, 2013 Sounds like a game plan. To be honest I would never use proin with one of my hounds. The "bad" side effects seen with DES is not really an issue with the low dosage we use to control incontentence. My girl had a stroke while taking Proin. Quote Mary in Houston Everyone has a photographic memory, but not everyone has film. LAND OF THE FREE BECAUSE OF THE BRAVE Link to comment Share on other sites More sharing options...
Burpdog Posted December 31, 2013 Share Posted December 31, 2013 Do a urine check with urinalysis not just at the vet's office. They have to send it off Quote Diane & The Senior Gang Burpdog Biscuits Link to comment Share on other sites More sharing options...
tbhounds Posted December 31, 2013 Share Posted December 31, 2013 My girl had a stroke while taking Proin. Sorry to hear that--was always a fear of mine. One of my girls almost died after her first and only dose. She did very well on DES for years. Too my vets place these girls on proin without checking for proteinuria nor blood pressures. Quote Link to comment Share on other sites More sharing options...
Guest peacehound Posted December 31, 2013 Share Posted December 31, 2013 a stroke is so scary, sorry to see this. I am always afraid to give my girl meds, she takes Adequan injections that help her get around and Tramadol for pain. As long as she is on her meds, she eats with gusto, roaches constantly and enjoys several mini walks a day. I always hope I will be able to help her pass to the bridge when it is time and not be blinded by love for her but so far she seems to really enjoy retirement. Quote Link to comment Share on other sites More sharing options...
tbhounds Posted January 1, 2014 Share Posted January 1, 2014 Please don't worry about starting the DES--as I mentioned before it's a very safe drug when you use the very low dose needed to control the urinary incontentence. Happy new year ;-) Quote Link to comment Share on other sites More sharing options...
cleptogrey Posted January 2, 2014 Share Posted January 2, 2014 felix was on des, it was a short period of time. i don't remember the exact sequencing of dosage. but it worked for nearly a year. then he was put on proin. he weighs 76#- first week 1/2 50mg tab 2xs a day 2nd week 1/2 50 mg tab daily 3rd week 1/2 50 mg tab every other day. that's what he's been on, tight as a drum. i must admit that when i was camping i sometimes stretched it to every 3 days since i really wasn't keeping track of time. i am surprised to see how high many dosages are. btw, my cool whip containers are always washed in the dishwasher-----let's see if your vet asks you if you want the container back, as mine always does! Quote Link to comment Share on other sites More sharing options...
Burpdog Posted January 2, 2014 Share Posted January 2, 2014 With DES you have to check platelets! Quote Diane & The Senior Gang Burpdog Biscuits Link to comment Share on other sites More sharing options...
winnie Posted January 2, 2014 Share Posted January 2, 2014 We have two seniors on Proin. They've been on it for years. Darcy is about 62# and Bonny is 75#. Each get 50mg daily. Both started off on 25mg. No problems. To the OP, I agree with checking for a UTI first. Quote Laura with Celeste (ICU Celeste) and Galgos Beatrix and Encarna The Horse - Gracie (MD Grace E) Bridge Angels Faye Oops (Santa Fe Oops), Bonny (Bonny Drive), Darcy (D's Zipperfoot) Link to comment Share on other sites More sharing options...
tbhounds Posted January 2, 2014 Share Posted January 2, 2014 (edited) With DES you have to check platelets!Actually you need to check reds and white cells too--the one side effect that everyone fears is bone marrow suppression. Again, at the low doses used to control spay incontinence it's not a huge factor. One should of course be careful and monitor bloods. Edited January 2, 2014 by tbhounds Quote Link to comment Share on other sites More sharing options...
Guest peacehound Posted January 2, 2014 Share Posted January 2, 2014 thanks all for your input and suggestions. Peace gets her bloodwork done every six months, will she have to be monitored even closer? Quote Link to comment Share on other sites More sharing options...
MaryJane Posted January 2, 2014 Share Posted January 2, 2014 If you are bringing in a urine to check for UTI, I suggest that you pick up a sterile one from the vet and use that. Otherwise, the container that you use will be contaminated. Make sure that they send it off to be cultured even if they are not seeing anything under the microscope. Lucy was on DES for a few months until we finally got the UTI under control. Quote Link to comment Share on other sites More sharing options...
greyhead Posted January 3, 2014 Share Posted January 3, 2014 (edited) We use butter containers that have been through the dishwasher, sometimes on the antibiotic anti-bacterial cycle, sometimes not. My vet was impressed that one sample we brought in such a container grew NOTHING when cultured. The vets said the ones at their office are not sterile...just very clean, like my washed butter containers. Edited January 3, 2014 by greyhead Quote Mary with Jumper Jack (2/17/11) and angels Shane (PA's Busta Rime, 12/10/02 - 10/14/16) and Spencer (Dutch Laser, 11/25/00 - 3/29/13). Link to comment Share on other sites More sharing options...
tbhounds Posted January 3, 2014 Share Posted January 3, 2014 thanks all for your input and suggestions. Peace gets her bloodwork done every six months, will she have to be monitored even closer? Most vets will just monitor her CBC -most likely they will be ok with every 6 months. Quote Link to comment Share on other sites More sharing options...
greyhoundlov Posted January 3, 2014 Share Posted January 3, 2014 I just think it's interesting that they pulled all the human meds containing PPA (?) off the shelves but continue to prescribe it for dogs. Quote Mary in Houston Everyone has a photographic memory, but not everyone has film. LAND OF THE FREE BECAUSE OF THE BRAVE Link to comment Share on other sites More sharing options...
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