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Found 6 results

  1. This may be being posted for a second time because I cannot find my first post. If it is a duplicate, I apologize. If this post comes across cold, it is not meant to, it just is the way I type because of the business I am in. Unfortunately, my business is very fact oriented and I have gotten accustomed to typing that way. My 12.5 year old baby, Charlie, has been diagnosed with stage 3 lymphoma. I am bound and determined to do everything possible for him to stay alive so long as he has a good quality of life. Timeline: 4/26/18 - had blood work done and he was in perfect health (including his teeth). 6/9/18 - my boyfriend felt some lumps in my baby's neck that were not there a few days before (we check him over as a habit as we are petting him). 6/10/18 - took Charlie to the vet had an aspirate done of the lymph nodes behind his knees. 6/12/18 - the aspirate comes back as "inconclusive; however, high probability of large cell lymphoma). 6/14/18 - went to the oncologist and he has been diagnosed with stage 3 lymphoma and started him on the CHOP treatment with the first chemo treatment 6/14. He had lost 3 pounds between 4/26 and 6/10, but had put them back on as of 6/14. I have a some questions that I'm hoping my fellow greyhound owners will be able to help me with. Does anyone know of a vet oncologist that is located in the South Florida area and either specializes in greyhounds or is very knowledgeable with greyhounds and cancer treatment? I know greyhounds have certain differences from other dogs (i.e. bigger heart, different normal blood level ranges, etc.). Does anyone know if there is a different and more successful treatment when it comes to lymphoma? My research has shown that chemo is the best treatment for lymphoma, but I don't know if there is anything that can be added to the CHOP treatment that can make it more successful in beating lymphoma in greyhounds. I want to treat his body as a whole and not just do chemo as treatment and hope for the best. Does anyone have any diet recommendations? I currently have Charlie on Merrick grain free texas beef and sweet potato as a dry food. Meal toppers include turkey, pork, beef and beef hearts (yes, I know that beef hearts are part of the beef category, but they are his favorite, so I felt the need to mention them separately). I make sure that I trim off as much as the fat as I can because I don't want him to have pancreatitis. After dinner desserts are beef marrow bones and either fat free plain yogurt or fat free plain greek yogurt. Treats are either chicken hearts or chicken gizzards (can you tell he's spoiled yet?). After my initial vet told me he suspected lymphoma, I started Charlie on vitamin c (500 mg 2x daily), b complex (1 daily) and fish oil (1 daily). Does anyone have any other ideas for supplements? I've seen some comments on websites saying turmeric helps as well; however, my current oncologist doesn't want to give him too may antioxidants because of the chemo. Anyone have any other ideas? My baby and I have been through a lot and I refuse to give up without a fight. Any ideas to fight this horrible cancer would be most appreciated.
  2. This morning, my grey Speed Racer (racing name Tipp Josiah) was diagnosed with lymphoma. The vet called it high grade and gave me two options. Option one: We can make him comfortable for the next couple of months with prednisone. He may survive one or two months. Option two: We can treat aggressively with chemotherapy. She is referring me to an oncology specialist and let me know to expect ultrasounds, x-rays, and biopsies. Can you tell me your experience with these two options? My dog is 9 years old. I don't want to traumatize him if I'm only buying a few extra low-quality-of-life months with him. I don't want to be selfish. But if chemo will make him feel a lot better and gives him a significantly better quality of life, I am happy to spend the money. Thank you for your help.
  3. Romie perked up after a couple of weeks of tramadol for his arthritis pain, but then started acting quieter again. Saturday I could feel lumps in his neck. Vet today found swollen lymph glands all over. Took a fine needle aspirate to confirm -- results later this week. Probably multicentric lymphoma. I'm starting to research the possibilities. Right now, he's eating fine; stools are a little on the soft side. I'm scared he'll suddenly nosedive, even before the aspirate results are back. Vet doesn't want to start with prednisone before results are back if we don't have to. I forget the reason -- I'm still a little shaky. Assuming he'll make it to the end of the week, I'm leaning toward either chemo with the Wisconsin-Madison/CHOP/whatever-it's-called protocol, or only palliative care. Cost and how Romie reacts will be the major factors. We live in a rural area, and there's not any vet oncologists closer than 60 miles. I need to discuss cost with my vet, and ask OSU if the greyhound program is providing any lymphoma drugs (other GT'ers seem to have gotten both yes and no answers recently from OSU). But do people know of any possible cost reduction methods for the chemo protocol? The dogs get the medication through IV, right? So it has to be done at the vet's? I see there is an oral med, leukeran (sp?), but it doesn't seem to be as effective as the combo of drugs with Wisconsin-Madison? Romie's "roman nose lite" profile:
  4. Guest

    Gi Lymphoma

    We adopted our lovely Kiowa about 5 years ago and she is our silly sassy girl who is loved by everyone! She is 7 years old, and has a brother, Raider (also a grey). Last Thursday, I noticed she was drinking an excessive amount of water and urinating more frequently than normal. By Friday, she seemed weaker and had some diarrhea. She wouldn't eat dinner that evening (we Grey owners KNOW that means something is wrong!). I took her to the Vet immediately and they saw blood in her urine and stool. They gave me special food and some antibiotics and sent us home for the weekend; but the Vet knew something more was wrong. She was still drinking A LOT of water, and ate the special food on Saturday. She also started vomiting and more diarrhea. By Sunday morning, she would not eat again. I cooked her some chicken and rice, which she ate, and was able to keep down. However, by Monday morning she lost her appetite again and we were referred to the Emergency Vet for an ultrasound. By Tuesday the test results confirmed it was Lymphoma (GI tract). We were devastated and amazed at how quickly the symptoms showed up--she was healthy JUST a few days ago. The Vet gave us 3 options: 1. Chemotherapy, 2. Steroids (prednisone) 3. (I don't want to talk about that option yet...). The Vet told us that her response to the prednisone will make her feel better short term by shrinking the tumor and be a good indicator of how she will respond to the Chemo. After a shot of prednisone last night, she finally ate breakfast this morning. They also told us after 4 weeks of Chemo, we should be able to see if it is helping her into remission or not. We feel positive about trying Chemo right now because we still see the light in her eyes and wag in her tail. We definitely don't want her to suffer though any treatment though. I am looking for any helpful advice from those who have experienced GI tract lymphoma. I am bringing Kiowa home today and thinking about things like special food that may help keep her strong through treatment or other helpful hints or resources anyone may know of. Thank you.
  5. From yesterday's paper. Notice the bold section near the end, about the researchers' desire to make the lymphoma and other drugs (cheaply) and "test market" them through sales to pet dogs -- they'd be human drugs that are already approved after testing them on dogs, but now manufactured in a vastly cheaper and different way, making them affordable for pets for the first time, according to the radio interview I heard this morning. Might be worth sharing with vets or watching for. I know it won't help those already suffering , but it's a bright spot on the horizon. Let's hope a vet pharm signs on (and keeps the drugs affordable rather than pocketing the 90% cheaper manufacturing process). San Diego Union Tribune 12/11/2012, Page A01 ALGAE CAN SLASH BIOTECH DRUG COSTS, PAPER SAYS Manufacturing method would bemuch cheaper, says scientist at UCSD BRADLEY J. FIKES • U-T Expensive biotech drugs now made in high-tech manufacturing plants can be grown much more cheaply in genetically engineered algae, according to a paper published Monday in the prestigious Proceedings of the National Academy of Sciences. Manufacturing costs can be reduced by 90 percent for these drugs, translating into half off their sales price, said Stephen Mayfield, a UC San Diego professor and senior author of the paper. The savings would provide financial relief to patients, health insurers and the federal government. The technology could make obsolete the manufacturing plants that grow specialized mammal cells in carefully monitored and chemically controlled vats, plants that cost hundreds of millions to build. SEE ALGAE • A9 UCSD’s Stephen Mayfield holds a colony of green algae specimens being cultured in his lab. JOHN GIBBINS • U-T Article Continued Below See ALGAE on Page A09 ALGAE • Dogswill be the first beneficiaries of the lower-cost drugs FROM A1 In their place would stand greenhouses containing transparent plastic bags filled with algae, water and diluted fertilizer. In Mayfield’s vision, scientists will design drugs on a computer, get the appropriate DNA by mail order from a manufacturer, then slip the DNA into the algae of choice. Ramping up production would be simply a matter of adding more bags. In the paper, Mayfield and colleagues demonstrated they could make an anti-cancer biotech drug identical to the original one now under development by a biotech company. Moreover, they tested it in mice and found that it had the same anti-cancer effect. David Hansen, chief executive of San Diego-based MabVax, said the algae method of manufacturing is of interest if it works. The company is developing antibody-based vaccines. “Any innovation in the area would be of benefit,” Hansen said. The paper is the culmination of seven years of work by Mayfield, director of the San Diego Center for Algae Biotechnology, and his colleagues. They used a common algae called Chlamydomonas reinhardtii, regarded by algae biologists as a model research organism. It’s found in soil and fresh water. The earliest biotech drugs, such as insulin, were made in genetically engineered bacteria. But more complicated medications developed later couldn’t be made in bacteria, so they are made in the cells of mammals, the most commonly used are derived from the ovaries of Chinese hamsters. These Chinese hamster ovary, or CHO, cells are grown in temperature-controlled vats and provided with sugars and other nutrients. But bacteria also grow on the nutrients, Mayfield said, so keeping the vats sterile is a top concern. Algae, by contrast, evolved in the open, under varying temperatures and conditions of acidity and alkalinity, Mayfield said. And the dilute fertilizer that nourishes the algae doesn’t spur bacterial growth the way sugars do. “Algae require only trace minerals, fertilizer, and sunlight to be grown at scale, giving them the potential to produce recombinant proteins, including therapeutics, very inexpensively,” the paper stated. Algae biologist Ursula Goodenough, a specialist in Chlamydomonas reinhardtii, said in an email she was impressed by the research. “Wow — well this is a most exciting paper,” said Goodenough, a professor of biology at Washington University in St. Louis. More specifically, she said, the paper “greatly advances the potential use of algae to produce complex biological molecules for therapeutic and other uses.” Mayfield and colleagues grew a two-part cancer drug in algae that cannot be completely made in CHO cells. It consists of a molecular missile called a monoclonal antibody designed to seek out specific cancer cells, attached to a cell-killing toxin “warhead.” Such drugs can’t be made in mammalian cells, because the toxin kills them, Mayfield said. The antibody part is grown in cells, extracted and purified, then chemically fused to the toxin, and the batch is once again purified. But the toxin doesn’t kill the genetically engineered algae, so the entire drug can be made in one step, making the process far simpler and cheaper, Mayfield said. The paper is titled “Production of unique immunotoxin cancer therapeutics in algal chloroplasts.” Its first author was Miller Tran, a postdoctoral student in Mayfield’s lab. When Mayfield began his research, there was a lot of uncertainty about whether algae were up to the task of making complex proteins, he said. SoMayfield and colleagues started testing the limits of algae by producing progressively more complicated drugs in them. In July, Mayfield’s group teamed with another from UC San Diego led by Joseph Vinetz to publish a paper about making a potential malaria vaccine in algae. The need for low manufacturing costs is critical to get mass malaria immunization in the countries that need it most, Mayfield said. Dogs will be the first beneficiaries of these lower-cost drugs, Mayfield said. “You have to go through canines anyway to prove they’re safe and effective,” Mayfield said of the drugs, which are typically tested in large animals before reaching humans. So instead of conducting clinical trials in animals as a milestone to human therapy, Mayfield is looking for a veterinary biotech company that would like to develop a treatment for animals directly from the research. “You would never do this with traditional technologies,” Mayfield said. “You can make the best canine drug in the world, but if it’s too expensive, you’ll never sell it. What we can do is make one for canine lymphomas, make it cheap enough to sell, and that is the proof of concept we should make these things for humans.” If dogs are able to get inexpensive treatments, the public will demand that they benefit from the same technology, Mayfield said. bradley.fikes@utsandiego.com (619) 293-1020 Twitter:@sandiegoscience UC San Diego professor Stephen Mayfield (left) and Miller Tran, a postdoctoral student in his lab, teamed up to write a paper. JOHN GIBBINS • U-T
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