Sugar just had her second injection (well, third really, she had two the first time around) It made a HUGE difference for her! She was so bad (arthritis) that the day before Thanksgiving, we had to carry her into the vet, she could only stumble a few steps before falling A course of Pred and lots of pain killers got her walking, but still slowly and painfully. About a week later, she got an acupuncture treatment and her first Adequan shot. Second shot a few days later, and a few days after that, she was running in the back yard! OK, short runs, but she obviously felt so much better. It lasted almost two months before I could tell she needed another shot. I know it doesn't work this well for all dogs, but that is the only negative I have heard of, sometimes it has little or no effect.