How does your dog behave when you are home? If she has a wild-eyed look and is on pins and needles while you're home, my first guess would be that she might be in pain -- especially since it seems to have come on suddenly. Panting when the dog is not hot is also a symptom of pain. (My second guess would be that something happened while she was in the crate. When I was a child I had a dog who slept in the kitchen with the doors shut. One night she barked and cried like crazy, which was completely unusual for her. Turns out there was a huge black snake that had found its way into the pantry by her bed.)
